2,6-Dichloropyrazine → HCID 58717083, compound

HRID 1244394

Reaction equation

HRID 1244394 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C@@H:7]([NH2:9])[CH3:8])=[CH:5][CH:4]=1.[Cl:12][C:13]1[CH:18]=[N:17][CH:16]=[C:15](Cl)[N:14]=1>>[Cl:12][C:13]1[N:14]=[C:15]([NH:9][C@H:7]([C:6]2[CH:10]=[CH:11][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH3:8])[CH:16]=[N:17][CH:18]=1

Participants

3

Reactant 2

HCID 785042,6-DichloropyrazineHCID 793467(S)-1-(4-Methoxyphenyl)ethylamine

Product 1

HCID 58717083HCID 58717083, compoundYield 79%

Procedure

In a procedure analogous to Example 1, reaction of 4-methoxy-α-(S)-methylbenzylamine (0.70 mg, 4.6 mmol) and 2,6-dichloropyrazine (0.6259 g, 4.20 mmol) furnished the product (873 mg, 79%).

Sources & evidence

ORD record
ord-5c1107af49da4086ad8afbfc7450a513
Source dataset
uspto-grants-2006_10
Patent number
US07122550B2

Linked notes

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