(+/-)-(3,3-Dimethyl-1-nitromethyl-cyclopentyl)-acetic Acid Ethyl Ester → HCID 21923172, compound
Reaction equation
C([O:3][C:4](=O)[CH2:5][C:6]1([CH2:13][N+:14]([O-])=O)[CH2:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7]1)C>[Ni].CO>[CH3:11][C:8]1([CH3:12])[CH2:9][CH2:10][C:6]2([CH2:13][NH:14][C:4](=[O:3])[CH2:5]2)[CH2:7]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
The ester 3 (380 mg, 1.6 mmol) and Raney Nickel (1 g) were suspended in methanol (75 mL) and shaken under a hydrogen atmosphere for 24 hours. The catalyst was removed by filtration, the filtrate concentrated to give the lactam 4 (246 mg, 94%) as a white solid.
Workup
- customThe catalyst was removed by filtration
- concentrationthe filtrate concentrated
Sources & evidence
- ORD record
- ord-a4328a571a1649658258e77b5f7d3282
- Source dataset
- uspto-grants-2006_10
- Patent number
- US07122678B2
Reaction notes
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