Dimethyl Sulfoxide → 3-Chloro-N-[1-(2-chlorophenyl)-2-[1-(2-fluoroethyl)-piperidin-4-ylmethoxy]ethyl]-1H-indole-6-carboxamide

HRID 124508

Reaction equation

HRID 124508 reaction equation
[Br:37][CH2:38][CH2:39][F:40].[C:31](=[O:32])([O-:33])[O-:34].[CH3:42][S:43]([CH3:44])=[O:45].[Cl:1][c:2]1[cH:3][nH:4][c:5]2[cH:6][c:7]([C:11](=[O:12])[NH:13][CH:14]([CH2:15][O:16][CH2:17][CH:18]3[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]3)[c:24]3[c:25]([Cl:30])[cH:26][cH:27][cH:28][cH:29]3)[cH:8][cH:9][c:10]12.[K+:35].[K+:36].[OH2:41]>>[Cl:1][c:2]1[cH:3][nH:4][c:5]2[cH:6][c:7]([C:11](=[O:12])[NH:13][CH:14]([CH2:15][O:16][CH2:17][CH:18]3[CH2:19][CH2:20][N:21]([CH2:38][CH2:39][F:40])[CH2:22][CH2:23]3)[c:24]3[c:25]([Cl:30])[cH:26][cH:27][cH:28][cH:29]3)[cH:8][cH:9][c:10]12

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 962WaterHCID 129822-Fluoroethyl bromideHCID 19660Carbonate IonHCID 693078883-chloro-N-[1-(2-chlorophenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide

Product 1

HCID 866036003-Chloro-N-[1-(2-chlorophenyl)-2-[1-(2-fluoroethyl)-piperidin-4-ylmethoxy]ethyl]-1H-indole-6-carboxamide

Sources & evidence

ORD record
ord-b56daee154044e849eb09a60ec95edae
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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