3-Chloro-2-methylbenzenesulfonyl chloride → HCID 9880612, compound

Reaction equation

[CH2:1]([C:3]1[S:7][C:6]([NH2:8])=[N:5][C:4]=1[CH3:9])[CH3:2].[Cl:10][C:11]1[C:12]([CH3:21])=[C:13]([S:17](Cl)(=[O:19])=[O:18])[CH:14]=[CH:15][CH:16]=1>>[Cl:10][C:11]1[C:12]([CH3:21])=[C:13]([S:17]([NH:8][C:6]2[S:7][C:3]([CH2:1][CH3:2])=[C:4]([CH3:9])[N:5]=2)(=[O:19])=[O:18])[CH:14]=[CH:15][CH:16]=1

Participants

Reactant 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chloride

HCID 127359565-Ethyl-4-methylthiazol-2-amine

Product 1

HCID 9880612HCID 9880612, compoundYield 25%

Procedure

The title compound was prepared from 5-ethyl-4-methyl-1,3-thiazol-2-ylamine (METHOD I) and 3-chloro-2-methylbenzenesulfonyl chloride according to METHOD A, yellow solid, 42 mg (25% yield): HRMS Calcd (found) for C13H15ClN2O2S2 m/z 330.0263 (330.0250).

Sources & evidence

ORD record: ord-3b46aad833124e5a94576376394d7acc
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07125900B2

Reaction notes

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