Pyrrolidine → 5-Bromo-2-(pyrrolidin-1-yl)pyrimidine

HRID 1245819

Reaction equation

Cl[C:2]1[N:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[NH:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1>>[N:9]1([C:2]2[N:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=2)[CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 6066655-Bromo-2-chloropyrimidine

Product 1

HCID 66220135-Bromo-2-(pyrrolidin-1-yl)pyrimidine

Procedure

Prepared from 2-chloro-5-bromopyrimidine and pyrrolidine by the method of Example 44 (b).

Sources & evidence

ORD record: ord-db7dde3011dc44a4a9b6988ec761d9ca
Source dataset: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07125896B2

Linked notes

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