4-(Aminomethyl)-3,5-difluorobenzonitrile hydrochloride → (RS)-N-(4-cyano-2,6-difluoro-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide

HRID 1247429

Reaction equation

HRID 1247429 reaction equation
Cl.[NH2:2][CH2:3][C:4]1[C:11]([F:12])=[CH:10][C:7]([C:8]#[N:9])=[CH:6][C:5]=1[F:13].[F:14][C:15]1[CH:20]=[C:19]([O:21][CH3:22])[CH:18]=[C:17]([F:23])[C:16]=1[CH:24]([O:28][CH2:29][CH3:30])[C:25](O)=[O:26]>>[C:8]([C:7]1[CH:6]=[C:5]([F:13])[C:4]([CH2:3][NH:2][C:25](=[O:26])[CH:24]([C:16]2[C:15]([F:14])=[CH:20][C:19]([O:21][CH3:22])=[CH:18][C:17]=2[F:23])[O:28][CH2:29][CH3:30])=[C:11]([F:12])[CH:10]=1)#[N:9]

Participants

3

Reactant 2

HCID 219055594-(Aminomethyl)-3,5-difluorobenzonitrile hydrochlorideHCID 21905754(RS)-(2,6-Difluoro-4-methoxy-phenyl)-ethoxy-acetic acid

Product 1

HCID 21904911(RS)-N-(4-cyano-2,6-difluoro-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide

Procedure

According to general procedure C 4-aminomethyl-3,5-difluoro-benzonitrile hydrochloride was reacted with (RS)-(2,6-difluoro-4-methoxy-phenyl)-ethoxy-acetic acid (example 101.3) give to (RS)-N-(4-cyano-2,6-difluoro-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide. Off-white solid. MS 397.1 ([M+H]+)

Sources & evidence

ORD record
ord-ef5204fa7dd64e1097c278046e9185b0
Source dataset
uspto-grants-2006_10
Patent number
US07129238B2

Linked notes

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