3-Chloro-3-(3-pyridinyl)-2-propenal → Phenyl[7-(3-pyridinyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone

HRID 1247951

Reaction equation

HRID 1247951 reaction equation
Cl[C:2]([C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1)=[CH:3][CH:4]=O.[NH2:12][C:13]1[C:17]([C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:19])=[CH:16][NH:15][N:14]=1>C(O)(=O)C>[C:20]1([C:18]([C:17]2[CH:16]=[N:15][N:14]3[C:2]([C:6]4[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=4)=[CH:3][CH:4]=[N:12][C:13]=23)=[O:19])[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 538697343-Chloro-3-(3-pyridinyl)-2-propenalHCID 178509267HCID 178509267, compound

Product 1

HCID 13475883Phenyl[7-(3-pyridinyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 0.02 mole of 3-chloro-3-(3-pyridinyl)-2-propenal and 0.02 mole of (3-amino-1H-pyrazol-4-yl)phenyl-methanone in 25 ml of glacial acetic acid was refluxed for 5 hours. The solvent was removed and the product isolated as described in Example 1, giving the desired product as crystals, mp 202°-203° C.

Workup

  1. temperaturewas refluxed for 5 hours
  2. customThe solvent was removed
  3. customthe product isolated

Sources & evidence

ORD record
ord-a23e9e4f3b364645902877e2a219b568
Source dataset
uspto-grants-1985_06
Patent number
US04521422

Linked notes

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