HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Chloride → 5-[4-(6-Fluoro-2-quinolyloxy)phenoxy]2,4-hexanedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Valerate | HCID 114781 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 2-(4-((6-Fluoro-2-quinolinyl)oxy)phenoxy)propionyl chloride | HCID 15070162 | — |
| Reactant | Methyl 2-acetyl-4-[4-(6-fluoro-2-quinolyloxy)phenoxy]-3-oxopentanoate | HCID 20278379 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 5-[4-(6-Fluoro-2-quinolyloxy)phenoxy]2,4-hexanedione | HCID 20278392 | — |
Reaction Steps
In the same manner, methyl 2-acetyl-4-[4-(6-fluoro-2-quinolyloxy)phenoxy]-3-oxopentanoate (XII; X' is fluoro and X" is hydrogen) is prepared from 2-[4-(6-fluoro-2-quinolyloxy)phenoxy]propionic acid chloride and the sodium salt of methylacetoacetate. This pentanoate is then heated with sodium chloride and DMSO to give 5-[4-(6-fluoro-2-quinolyloxy)phenoxy]2,4-hexanedione (XIII; X' is fluoro and X" is hydrogen).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04522647 |
| Source dataset | uspto-grants-1985_06 |
| ORD ID | ord-5dd37180b95f49ccae12bf69a9dafdee |
| Source note | uspto-grants-1985_06 |