Ethanol → Glycine, N-cyclohexyl-

HRID 1248550

Reaction equation

HRID 1248550 reaction equation
[NH2:1][CH2:2][C:3]([OH:5])=[O:4].[C:6]1(=O)[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.C(O)C>O.[Pd]>[CH:6]1([NH:1][CH2:2][C:3]([OH:5])=[O:4])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1

Participants

6

Reactant 3

HCID 702EthanolHCID 750GlycineHCID 7967Cyclohexanone

Product 1

HCID 42810Glycine, N-cyclohexyl-

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

338 g of glycine (4.5 mols) is dissolved in 1.5 liters of deionized water. The solution is put into a 1-gallon autoclave. 25 g of 10% Pd on C, 551 g of cyclohexanone (5.6 mols) and 500 ml of ethanol are added. Hydrogenation is carried out at 60° C. between 56.2 and 70.3 kg/cm2. In the course of three hours a pressure drop corresponding to 98.4 kg/cm2 is observed.

Workup

  1. customis carried out at 60° C.
  2. customIn the course of three hours

Sources & evidence

ORD record
ord-1c08be19be5049c8910ba5b48776a324
Source dataset
uspto-grants-1985_06
Patent number
US04525294

Linked notes

Loading…