Sodium Hydroxide → L74Uzx8twj
Reaction equation
[OH:1][CH2:2][C@H:3]1[C:15]2[NH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]=2[CH2:6][C@@H:5]([C:16]([O:18]C)=[O:17])[NH:4]1.[OH-].[Na+]>CO>[OH:1][CH2:2][C@H:3]1[C:15]2[NH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]=2[CH2:6][C@@H:5]([C:16]([OH:18])=[O:17])[NH:4]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
In the same manner as described in Reference Example 2-(1) using methyl (1RS,3RS)-cis-1-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (3.124 g), 1N NaOH (13.2 ml) and methanol (550 ml), there is obtained the title compound (2.66 g, 90%), m.p. 241°-242° C.
Sources & evidence
- ORD record
- ord-4afae077f3ad4119932b5943c2e17ec4
- Source dataset
- uspto-grants-1986_12
- Patent number
- US04628057
Reaction notes
Loading…