Thionyl Chloride → 2-Methyl-3-thiophenecarboxylate chloride
Reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([OH:9])=[O:8].S(Cl)([Cl:12])=O>>[Cl-:12].[CH3:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([O-:9])=[O:8]Participants
3
Procedure
2-Methyl-3-thiophenecarboxylic acid (54 g) was reacted with thionyl chloride (100 ml) at 60° C. for 1.5 hr. The reaction solution was evaporated, and to the resulting residue was added THF (100 ml×2), and then excess thionyl chloride was removed, to give 60.5 g of the title compound.
Workup
- customThe reaction solution was evaporated
- additionto the resulting residue was added THF (100 ml×2)
- customexcess thionyl chloride was removed
Sources & evidence
- ORD record
- ord-3cd658c25ea145a9ad3206bdedce722e
- Source dataset
- uspto-grants-2002_01
- Patent number
- US06340759B1
Reaction notes
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