Sodium Hydroxide → 2-(Octane-1-sulfonyl)3-[4-(2-piperidin-yl-ethoxy)phenyl]-propionic acid
Reaction equation
C([O:3][C:4](=[O:33])[CH:5]([S:22]([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])(=[O:24])=[O:23])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[CH:9][CH:8]=1)C.[OH-].[Na+]>C(O)C>[CH2:25]([S:22]([CH:5]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][N:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)=[CH:9][CH:8]=1)[C:4]([OH:33])=[O:3])(=[O:24])=[O:23])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]Participants
4
Procedure
2-(Octane-1-sulfonyl)-3-[4(2-piperidin-yl-ethoxy)-phenyl]-propionic acid was prepared according to the general method as outlined in example 9. Starting from 2-(octane-1-sulfonyl)-3-[4-(2-piperidin-yl-ethoxy)-phenyl]-propionic acid ethyl ester (8.9 g, 18 mmol), ethanol (25 mL) and 10 N sodium hydroxide (25 mL). Yield 6.0 g (72%).