N-Vinylpyrrolidine → Ethyl 6-Phenyl-5-p-tolyl-pyridine-2-carboxylate

HRID 12517

Reaction equation

HRID 12517 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([C:20]([O:22][CH2:23][CH3:24])=[O:21])N=N[C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:25](N1CCCC1)=[CH2:26]>C(Cl)(Cl)Cl>[C:1]1([C:7]2[N:8]=[C:9]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH:26]=[CH:25][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 3014294N-Vinylpyrrolidine2×HCID 59338808Ethyl 5-phenyl-6-p-tolyl-1,2,4-triazine-3-carboxylate2×

Product 1

HCID 25033077Ethyl 6-Phenyl-5-p-tolyl-pyridine-2-carboxylate

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Following General Procedure D, ethyl 5-phenyl-6-p-tolyl-1,2,4-triazine-3-carboxylate (Compound 12, 177 mg, 0.56 mmol) and crude 1-vinylpyrrolidine (Compound 38, 730 mg) in CHCl3 (10 ml) were reacted to produce the title compound as a yellow solid.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-0eef4f474e3b4844a43a01518b3416ad
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Linked notes

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