N-Vinylpyrrolidine → Ethyl 6-Phenyl-5-(4-propylphenyl)-pyridine-2-carboxylate

HRID 12519

Reaction equation

HRID 12519 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([C:22]([O:24][CH2:25][CH3:26])=[O:23])N=N[C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][CH3:21])=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:27](N1CCCC1)=[CH2:28]>C(Cl)(Cl)Cl>[C:1]1([C:7]2[N:8]=[C:9]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH:28]=[CH:27][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][CH3:21])=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 3014294N-Vinylpyrrolidine2×HCID 59338832Ethyl 5-phenyl-6-(4-propyl-phenyl)-1,2,4-triazine-3-carboxylate2×

Product 1

HCID 25033079Ethyl 6-Phenyl-5-(4-propylphenyl)-pyridine-2-carboxylate

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Following General Procedure D, ethyl 5-phenyl-6-(4-propyl-phenyl)-1,2,4-triazine-3-carboxylate (Compound 14), (153 mg, 0.46 mmol) and crude 1-vinylpyrrolidine (Compound 38, 2 g) in CHCl3 (10 ml) were reacted to produce the title compound as a yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-cd87c93174394e969ed9ef7c43a800f7
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Linked notes

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