N-Vinylpyrrolidine → Ethyl 5-Phenyl-6-p-tolyl-pyridine-2-carboxylate

HRID 12522

Reaction equation

HRID 12522 reaction equation
[C:1]1([C:7]2N=N[C:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[N:9][C:8]=2[C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:25](N1CCCC1)=[CH2:26]>C(Cl)(Cl)Cl>[C:1]1([C:7]2[CH:25]=[CH:26][C:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[N:9][C:8]=2[C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 3014294N-Vinylpyrrolidine2×HCID 25033076Ethyl 6-phenyl-5-p-tolyl-1,2,4-triazine-3-carboxylate2×

Product 1

HCID 25033080Ethyl 5-Phenyl-6-p-tolyl-pyridine-2-carboxylate

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Following General Procedure D, ethyl 6-phenyl-5-p-tolyl-1,2,4-triazine-3-carboxylate (Compound 17, 361 mg, 1.13 mmol) and crude 1-vinylpyrrolidine (Compound 38, 806 mg) in CHCl3 (10 ml) were reacted to produce the title compound as a yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-2411d3daac3b49a7a31ba7c021abc1c4
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Linked notes

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