N-Vinylpyrrolidine → Ethyl 6-(4-Ethylphenyl)-5-phenyl-pyridine-2-carboxylate

HRID 12523

Reaction equation

HRID 12523 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([C:21]([O:23][CH2:24][CH3:25])=[O:22])N=N[C:14]=2[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:5][CH:4]=1)[CH3:2].[CH:26](N1CCCC1)=[CH2:27]>C(Cl)(Cl)Cl>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH:27]=[CH:26][C:14]=2[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:5][CH:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 3014294N-Vinylpyrrolidine2×HCID 59338822Ethyl 5-(4-ethylphenyl)-6-phenyl-1,2,4-triazine-3-carboxylate2×

Product 1

HCID 59338818Ethyl 6-(4-Ethylphenyl)-5-phenyl-pyridine-2-carboxylate

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Following General Procedure D, ethyl 5-(4-ethylphenyl)-6-phenyl-1,2,4-triazine-3-carboxylate (Compound 18, 245 mg, 0.74 mmol) and crude 1-vinylpyrrolidine (Compound 38, 572 mg) in CHCl3 (10 ml) were reacted to produce the title compound as a yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-562ae536f62e4b34b4aefe73e07bb20a
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Linked notes

Loading…