N-Vinylpyrrolidine → Ethyl 5-phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate

HRID 12524

Reaction equation

HRID 12524 reaction equation
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([C:21]([O:23][CH2:24][CH3:25])=[O:22])N=N[C:14]=2[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[CH:28](N1CCCC1)=[CH2:29]>C(Cl)(Cl)Cl>[C:15]1([C:14]2[CH:28]=[CH:29][C:11]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[N:10][C:9]=2[C:6]2[CH:7]=[CH:8][C:3]([C:2]([F:27])([F:26])[F:1])=[CH:4][CH:5]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 3014294N-Vinylpyrrolidine2×HCID 59338807Ethyl 5-(4-trifluoromethylphenyl)-6-phenyl-1,2,4-triazine-3-carboxylate2×

Product 1

HCID 68407826Ethyl 5-phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Following General Procedure D, ethyl 5-(4-trifluoromethylphenyl)-6-phenyl-1,2,4-triazine-3-carboxylate (Compound 19, 1 g, 2.68 mmol) and crude 1-vinylpyrrolidine (Compound 38, 1.4 g) in CHCl3 (20 ml) were reacted to produce the title compound as a yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-44b6bfd75d794d3281b750bfa16d6f38
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Linked notes

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