Cyanamide → HCID 178511002, compound
Reaction equation
Cl.[NH2:2][C:3]1[CH:7]=[N:6][N:5]([CH2:8][CH2:9][CH2:10][CH2:11][C:12]#[N:13])[N:4]=1.[N:14]#[C:15][NH2:16]>CCO>[NH:2]([C:3]1[CH:7]=[N:6][N:5]([CH2:8][CH2:9][CH2:10][CH2:11][C:12]#[N:13])[N:4]=1)[C:15]([NH2:16])=[NH:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution 5-(4-amino-1,2,3-triazol-2-yl)valeronitrile hydrochloride (2.01 g.) in EtOH (15 ml.) was treated with cyanamide (0.42 g.) and the solution heated under reflux for 4.5 hours. A further 0.1 g. of cyanamide was added and heating under reflux was continued for 2 hours. The solution was evaporated and the residue basified with ammonia and continuously extracted for 24 hours with EtOAc to give a yellow oil which was purified by medium pressure chromatography using chloroform/MeOH/aqueous ammonia (s.g. 0.880) 8:2:0.1 v/v/v as eluant to give 5-(4-guanidino-1,2,3-triazol-2-yl)valeronitrile as a colourless oil (0.45 g.).