Picolinate → Methyl 5-(4-Ethylphenyl)-6-(pyridin-4-yl)pyridine-2-carboxylate

HRID 12542Notes

Reaction equation

HRID 12542 reaction equation
N1C=CC=CC=1C([O-])=O.[CH2:10]([C:12]1[CH:17]=[CH:16][C:15]([C:18]2[C:19]([C:29]3[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=3)=[N:20][C:21]([C:24]([O:26][CH2:27]C)=[O:25])=[CH:22][CH:23]=2)=[CH:14][CH:13]=1)[CH3:11]>OS(O)(=O)=O.CO>[CH2:10]([C:12]1[CH:13]=[CH:14][C:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24]([O:26][CH3:27])=[O:25])=[N:20][C:19]=2[C:29]2[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=2)=[CH:16][CH:17]=1)[CH3:11]

Participants

5

Reactant 2

HCID 6920223PicolinateHCID 68408497Ethyl 3-(4-Ethylphenyl)-[2,4']-bipyridinyl-6-carboxylate

Product 1

HCID 24752879Methyl 5-(4-Ethylphenyl)-6-(pyridin-4-yl)pyridine-2-carboxylate

Reagents, catalysts & solvents 2

HCID 1118Sulfuric AcidCatalystHCID 887MethanolSolvent

Procedure

Following General Procedure E, ethyl 5-(4-ethylphenyl)-6-(pyridine-4-yl)phenyl)pyridine-2-carboxylate (Compound 49, 48 mg, 0.14 mmol) and conc. H2SO4 (10 drops) in methanol were reacted to produce the title compound as a light yellow solid.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-36fda2b6e6234cea9f29b13440c68cbc
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Reaction notes

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