6-Chloro-m-anisidine → 2-Chloro-5-methoxybenzene-1-sulfonyl chloride

Reaction equation

F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([Cl:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[O:12][CH3:13].[Cl:14]C1C=CC(OC)=CC=1N>>[Cl:14][C:6]1[CH:7]=[CH:2][C:3]([O:12][CH3:13])=[CH:4][C:5]=1[S:8]([Cl:11])(=[O:10])=[O:9]

Participants

Reactant 2

HCID 754606-Chloro-m-anisidine

HCID 27834084-Fluoro-3-methoxybenzenesulfonyl chloride2×

Product 1

HCID 220335362-Chloro-5-methoxybenzene-1-sulfonyl chloride

Procedure

The titled compound is prepared analogously to 4-fluoro-3-methoxy-benzenesulfonyl chloride (Intermediate 102a) by replacing 4-fluoro-3-methoxyaniline with 2-chloro-5-methoxy-phenylamine.

Sources & evidence

ORD record: ord-c91fd2c2a30746a49e514c76afe019b9
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08455645B2

Reaction notes

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