Pentanamide → 2-Butyl-4-thiazolecarboxylic acid

HRID 1255292Notes

Reaction equation

CC[CH:3]([C:6]1[S:7][CH:8]=[C:9]([C:11]([O:13]CC)=[O:12])[N:10]=1)[CH2:4][CH3:5].[C:16](N)(=O)CCCC>>[CH2:3]([C:6]1[S:7][CH:8]=[C:9]([C:11]([OH:13])=[O:12])[N:10]=1)[CH2:4][CH2:5][CH3:16]

Participants

Reactant 2

HCID 12298Pentanamide

HCID 57989261Ethyl 2-(pentan-3-yl)thiazole-4-carboxylate

Product 1

HCID 140500762-Butyl-4-thiazolecarboxylic acid

Procedure

Prepared by the method of Carboxylic Acid 3, from step b using pentanamide (10 g) in place of 2-ethylbutanamide in step b. Yield 4.6 g.

Sources & evidence

ORD record: ord-d5848872d77b4527aa84513355e3441c
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08455483B2

Reaction notes

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