N,N'-Dimethylethylenediamine → 1-(5,6-Diphenyl-pyrazin-2-yl)-propan-1-one

HRID 12568

Reaction equation

HRID 12568 reaction equation
[C:1]1([C:7]2[N:8]=[CH:9][C:10]([C:19]([O:21]C)=O)=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Al](CC)(CC)[CH2:24][CH3:25].CNCCNC>C1(C)C=CC=CC=1>[C:1]1([C:7]2[N:8]=[CH:9][C:10]([C:19](=[O:21])[CH2:24][CH3:25])=[N:11][C:12]=2[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 8070N,N'-DimethylethylenediamineHCID 16682930TriethylaluminumHCID 25033170Methyl 5,6-Diphenyl-pyrazine-2-carboxylate2×

Product 1

HCID 112315431-(5,6-Diphenyl-pyrazin-2-yl)-propan-1-one

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Following General Procedure O, methyl 5,6-diphenyl-pyrazine-2-carboxylate (Compound 93) (92 mg, 0.32 mmol), Et3Al (0.9 ml, 1M in hexane), DMEDA (38 mg, 0.35 mmol) in toluene was reacted to afford the title compound.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-c266ff78267141f78cd7efceb38cee8f
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Linked notes

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