[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]#[C:8][C:9]2[CH:10]=[C:11]([C:19]3[N:20]=[C:21]([CH2:24][N:25]4[CH:29]=[C:28]([C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH:27]=[N:26]4)[S:22][CH:23]=3)[CH:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:14]=2)[CH:2]=1.N1C=CC=CC=1>C(O)C.S([O-])([O-])(=O)=O.[Ba+2].[Pd+2].S([O-])([O-])(=O)=O>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3](/[CH:7]=[CH:8]\[C:9]2[CH:10]=[C:11]([C:19]3[N:20]=[C:21]([CH2:24][N:25]4[CH:29]=[C:28]([C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH:27]=[N:26]4)[S:22][CH:23]=3)[CH:12]=[C:13]([C:15]([F:16])([F:17])[F:18])[CH:14]=2)[CH:2]=1To a solution (10 mL) of the compound (980 mg, 2.0 mmol) obtained in Example 87a in ethanol were added pyridine (480 mg, 6.1 mmol) and palladium-barium sulfate (490 mg), and the mixture was stirred at room temperature for 5 hr under a hydrogen atmosphere (1 atm). Palladium-carbon was removed and the solvent was evaporated under reduced pressure. The resulting crude title compound was purified by column chromatography (hexane-hexane/ethyl acetate=35/65) to give the title compound (450 mg, 46%) as colorless crystals.
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