Acetyl chloride → N-(6-Chloro-2-fluoro-3-methyl-phenyl)-acetamide
Reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[Cl:5][C:6]1[C:11]([NH2:12])=[C:10]([F:13])[C:9]([CH3:14])=[CH:8][CH:7]=1>C1(C)C=CC=CC=1>[Cl:5][C:6]1[C:11]([NH:12][C:1](=[O:3])[CH3:2])=[C:10]([F:13])[C:9]([CH3:14])=[CH:8][CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Acetylchloride (2.56 mL, 36.0 mmol) was added to a mixture of 6-chloro-2-fluoro-3-methyl-aniline (5.00 g, 31.3 mmol) and toluene (200 mL), additional toluene (50 mL) was added and the mixture was heated to reflux for 3 h. The reaction mixture was cooled with an ice bath and the formed precipitate was filtered off, washed with cold toluene and dried.
Workup
- additionwas added
- temperaturethe mixture was heated
- temperatureto reflux for 3 h
- temperatureThe reaction mixture was cooled with an ice bath
- filtrationthe formed precipitate was filtered off
- washwashed with cold toluene
- customdried
Sources & evidence
- ORD record
- ord-0e22098751bb4466a5fda6b2637c0c9d
- Source dataset
- uspto-grants-2013_06
- Patent number
- US08466186B2
Reaction notes
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