4-Cyanopiperidine → HCID 54591444, compound

Reaction equation

Br[C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][CH:30]=1)[CH2:5][N:6]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[O:16][N:15]=[C:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=3)[N:13]=2)=[N:7]1.[C:31]([CH:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1)#[N:32]>>[CH3:11][C:10]1[N:6]([CH2:5][C:4]2[CH:3]=[C:2]([N:36]3[CH2:37][CH2:38][CH:33]([C:31]#[N:32])[CH2:34][CH2:35]3)[CH:30]=[CH:29][CH:28]=2)[N:7]=[C:8]([C:12]2[O:16][N:15]=[C:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=3)[N:13]=2)[CH:9]=1

Participants

Reactant 2

HCID 1382234-Cyanopiperidine

HCID 58072149HCID 58072149, compound

Product 1

HCID 54591444HCID 54591444, compound

Procedure

Analogously to the process described in Example 8, 150 mg (0.313 mmol) of the compound from Example 1A and 69 mg (0.626 mmol) of 4-cyanopiperidine were used to obtain 68 mg (43% of theory) of the title compound.

Sources & evidence

ORD record: ord-1351541fc8ba409f952a5bccabf17f40
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08470811B2

Reaction notes

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