2-Aminomethyl-1,4-benzodioxane → HCID 68662181, compound

Reaction equation

[C:1]([CH:3]([CH:7]1[C:11]([Cl:12])=[C:10](Cl)C(=O)O1)[C:4]([NH2:6])=[O:5])#[N:2].[O:15]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[O:18][CH2:17][CH:16]1[CH2:25][NH2:26]>>[ClH:12].[Cl:12][C:11]1[CH:7]=[C:3]([C:4]([NH2:6])=[O:5])[C:1](=[NH:2])[N:26]([CH2:25][CH:16]2[O:15][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=3[O:18][CH2:17]2)[CH:10]=1

Participants

Reactant 2

HCID 150532-Aminomethyl-1,4-benzodioxane

HCID 5417922-Cyano-2-(3,4-dichloro-5(2H)-oxo-2-furyl)acetamide

Product 1

HCID 68662181HCID 68662181, compound

Procedure

According to the method of Example 160, 2-cyano-2-(3,4-dichloro-5-oxo-2,5-dihydrofuran-2-yl)acetamide was reacted with 1-(2,3-dihydro-1,4-benzodioxin-2-yl) methanamine to give the title compound.

Sources & evidence

ORD record: ord-3f1b8e4c1d234e1391615ebe8584a126
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08470859B2

Reaction notes

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