Thionyl Chloride → HCID 58087452, compound

Reaction equation

[CH2:1]([S:4]([NH:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11](O)=[O:12])(=[O:6])=[O:5])[CH2:2][CH3:3].S(Cl)([Cl:19])=O>>[CH2:1]([S:4]([NH:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11]([Cl:19])=[O:12])(=[O:6])=[O:5])[CH2:2][CH3:3]

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 162282623-(Propane-1-sulfonamido)benzoic acid

Product 1

HCID 58087452HCID 58087452, compound

Procedure

A solution of 3-(propane-1-sulfonylamino)-benzoic acid (76, 1.20 g, 4.93 mmol) in thionyl chloride was heated to reflux for 3.0 hours. Evaporation of the solvent gave compound 77 as white solid that was used for the next step.

Workup

temperatureto reflux for 3.0 hours
customEvaporation of the solvent

Sources & evidence

ORD record: ord-acd0f00ba1ce45a1927d95672fbd4cef
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08470818B2

Reaction notes

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