Morpholine → 2-Methoxy-4-[2-(morpholin-4-yl)ethyl]aniline

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15]N(C)[CH2:13][CH2:12]2)[CH:6]=[CH:5][C:4]=1[NH2:18].N1CC[O:22]CC1>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][O:22][CH2:13][CH2:12]2)[CH:6]=[CH:5][C:4]=1[NH2:18]

Participants

Reactant 2

HCID 8083Morpholine

HCID 574161632-Methoxy-4-[2-(4-methylpiperazin-1-yl)ethyl]aniline

Product 1

HCID 574161152-Methoxy-4-[2-(morpholin-4-yl)ethyl]aniline

Procedure

2-Methoxy-4-(2-morpholin-4-yl-ethyl)-phenylamine was prepared in a similar manner as 2-Methoxy-4-[2-(4-methyl-piperazin-1-yl)-ethyl]-phenylamine of Example 488 replacing 1-Methyl-piperazine with morpholine. LC/MS (E/I+) 237.07 (M+H).

Sources & evidence

ORD record: ord-ecf8ced7838548d2a59e6fcb0b560c39
Source dataset: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08471005B2

Reaction notes

Loading…