Methyl 3-[5-methyl-oxazol-4-yl]-benzoate → 3-[3-(5-Methyl-oxazol-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester
Reaction equation
CO[C:3](=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:11]=[CH:12][O:13][C:14]=2[CH3:15])[CH:5]=1.[C:17]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])(=[O:19])[CH3:18].[Li]>>[C:21]([O:20][C:17](=[O:19])[CH2:18][C:3]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:11]=[CH:12][O:13][C:14]=2[CH3:15])[CH:5]=1)=[O:16])([CH3:24])([CH3:23])[CH3:22]Participants
3
Procedure
3-(5-methyl-oxazol-4-yl)-benzoic acid methyl ester (0.87 g) was treated with lithium tert.-butyl acetate according to the general procedure K (method b) to give crude 3-[3-(5-methyl-oxazol-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (1.46 g) as a pale-yellow oil.
Sources & evidence
- ORD record
- ord-c0683358a61d49169984079afc890474
- Source dataset
- uspto-grants-2003_04