6-(3-Imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one → HCID 86586909, compound
Reaction equation
[C:1]([O:5][C:6](=[O:28])[NH:7][C:8]1[C:13]([NH2:14])=[CH:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[C:10]([O:22][CH2:23][C:24]([F:27])([F:26])[F:25])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[N:29]1([C:34]2[CH:35]=[C:36]([C:40]3[O:45]C(C)(C)[O:43][C:42](=O)[CH:41]=3)[CH:37]=[CH:38][CH:39]=2)[CH:33]=[CH:32][N:31]=[CH:30]1>>[C:1]([O:5][C:6](=[O:28])[NH:7][C:8]1[C:13]([NH:14][C:42](=[O:43])[CH2:41][C:40]([C:36]2[CH:37]=[CH:38][CH:39]=[C:34]([N:29]3[CH:33]=[CH:32][N:31]=[CH:30]3)[CH:35]=2)=[O:45])=[CH:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[C:10]([O:22][CH2:23][C:24]([F:25])([F:26])[F:27])[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]Participants
3
Procedure
The title compound was prepared from [5-amino-2′-fluoro-2-(2,2,2-trifluoro-ethoxy)-biphenyl-4-yl]-carbamic acid tert.-butyl ester (Example J5) (200 mg, 0.5 mmol) and 6-(3-imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one (Example L3) (160 mg, 0.5 mmol) according to the general procedure M. Obtained as an amorphous brown substance (167 mg).
Workup
- customObtained as an amorphous brown substance (167 mg)