2-Methoxyethanol → 5-(2-Methoxy-ethoxy)-2-nitro-4-pyrrol-1-yl-phenylamine

HRID 1266729

Reaction equation

HRID 1266729 reaction equation
Cl[C:2]1[C:3]([N:12]2[CH:16]=[CH:15][CH:14]=[CH:13]2)=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:8])[CH:7]=1.[CH3:17][O:18][CH2:19][CH2:20][OH:21].[OH-].[K+]>CS(C)=O>[CH3:17][O:18][CH2:19][CH2:20][O:21][C:2]1[C:3]([N:12]2[CH:16]=[CH:15][CH:14]=[CH:13]2)=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:8])[CH:7]=1

Participants

5

Reactant 3

HCID 80192-MethoxyethanolHCID 14797Potassium HydroxideHCID 185488595-Chloro-2-nitro-4-pyrrol-1-yl-phenylamine

Product 1

HCID 185487435-(2-Methoxy-ethoxy)-2-nitro-4-pyrrol-1-yl-phenylamine

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The title compound was prepared from 5-chloro-2-nitro-4-pyrrol-1-yl-phenylamine (Example F3) (1.01 g, 4 mmol), 2-methoxyethanol (1.58 mL, 20 mmol) and KOH (316 mg, 4.8 mmol) in DMSO (5 mL) according to the general procedure E. Obtained as an orange solid (870 mg).

Sources & evidence

ORD record
ord-9e9db5af966b4cfca83cab6f3020956a
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Linked notes

Loading…