Methanol → 5-Methoxy-2-nitro-4-pyrrol-1-yl-phenylamine

HRID 1266730

Reaction equation

HRID 1266730 reaction equation
Cl[C:2]1[C:3]([N:12]2[CH:16]=[CH:15][CH:14]=[CH:13]2)=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:8])[CH:7]=1.[CH3:17][OH:18].[OH-].[K+]>CS(C)=O>[CH3:17][O:18][C:2]1[C:3]([N:12]2[CH:16]=[CH:15][CH:14]=[CH:13]2)=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:8])[CH:7]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 185488595-Chloro-2-nitro-4-pyrrol-1-yl-phenylamine

Product 1

HCID 185487175-Methoxy-2-nitro-4-pyrrol-1-yl-phenylamine

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The title compound was prepared from 5-chloro-2-nitro-4-pyrrol-1-yl-phenylamine (Example F3) (5.94 g, 25 mmol), methanol (25 mL) and KOH (1.98 g, 30 mmol) in DMSO (25 mL) according to the general procedure E. Obtained as an orange solid (5.88 g).

Sources & evidence

ORD record
ord-e6ee15db5ebc44d9980b62679a2b0bb5
Source dataset
uspto-grants-2003_04
Patent number
US06548495B2

Linked notes

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