4-Methyloxybenzyl chloride → n-(2,6-Dimethylphenyl)-2-[4-(2-hydroxy-5-phenylpentyl)piperazinyl]acetamide

HRID 1267028

Reaction equation

HRID 1267028 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10](=[O:31])[CH2:11][N:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH:19]([OH:30])[CH2:20][CH2:21]C2C=CC(OC)=CC=2)[CH2:14][CH2:13]1.CO[C:34]1[CH:41]=[CH:40][C:37]([CH2:38]Cl)=[CH:36][CH:35]=1>>[CH3:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[C:3]=1[NH:9][C:10](=[O:31])[CH2:11][N:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH:19]([OH:30])[CH2:20][CH2:21][CH2:38][C:37]2[CH:40]=[CH:41][CH:34]=[CH:35][CH:36]=2)[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 699934-Methyloxybenzyl chlorideHCID 12052937N-(2,6-dimethylphenyl)-2-{4-[4-(4-methoxyphenyl)-2-hydroxybutyl]piperazinyl}acetamide

Product 1

HCID 10158442n-(2,6-Dimethylphenyl)-2-[4-(2-hydroxy-5-phenylpentyl)piperazinyl]acetamide

Procedure

Compound 25 was prepared in a manner similar to that of 16, substituting phenethyl chloride for 4-methoxybenzyl chloride in part A. (M+1)=410.4.

Sources & evidence

ORD record
ord-b718d0ac97c94f00a005ad817129ad0b
Source dataset
uspto-grants-2003_04
Patent number
US06552023B2

Linked notes

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