3,4,5-Trifluorobenzaldehyde → 2-(3,4,5-Trifluorophenyl)oxirane

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:11])[C:9]=1[F:10])[CH:5]=[O:6].[CH3:12]CCCC.C(OCC)C>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]2[O:6][CH2:12]2)[CH:7]=[C:8]([F:11])[C:9]=1[F:10]

Participants

Reactant 2

HCID 27769543,4,5-Trifluorobenzaldehyde

HCID 21877078Diethylether pentane

Product 1

HCID 225744002-(3,4,5-Trifluorophenyl)oxirane

Procedure

Following General Procedure EC and using 3,4,5-trifluorobenzaldehyde (Strem), the title compound was isolated after flash chromatography with 10:1 pentane/diethylether.

Sources & evidence

ORD record: ord-2f284ea4c7554799a8ef0c6a02c3f2b3
Source dataset: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06552013B1

Reaction notes

Loading…