2-Bromophenylacetic acid → 2-[(2-Chloro-3-methylphenyl)amino]phenylacetic acid

Reaction equation

Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10].[Cl:12][C:13]1[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][C:14]=1[NH2:15]>>[Cl:12][C:13]1[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][C:14]=1[NH:15][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10]

Participants

Reactant 2

HCID 877542-Bromophenylacetic acid

HCID 114124382-Chloro-m-toluidine

Product 1

HCID 147629482-[(2-Chloro-3-methylphenyl)amino]phenylacetic acid

Procedure

In the manner described in example 3, 2-bromophenylacetic acid is condensed with 2-chloro-3-methylaniline to yield 2-[(2-chloro-3-methylphenyl)amino]phenylacetic acid.

Sources & evidence

ORD record: ord-3ddb2998832645b5b9c5fde5e74afede
Source dataset: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06552077B2

Reaction notes

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