2,3-Dimethylaniline → HCID 20481270, compound

HRID 126833

Reaction equation

HRID 126833 reaction equation
Cl.[Cl:2][CH2:3][C:4]1[NH:5][CH2:6][CH2:7][N:8]=1.[CH3:9][C:10]1[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:11]=1[NH2:12]>C(O)C>[ClH:2].[CH3:9][C:10]1[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:11]=1[NH:12][CH2:3][C:4]1[NH:5][CH2:6][CH2:7][N:8]=1

Participants

4

Reactant 2

HCID 68932,3-DimethylanilineHCID 27609282-(chloromethyl)-4,5-dihydro-1H-imidazole hydrochloride

Product 1

HCID 20481270HCID 20481270, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

31 g of 2-chloromethyl-2-imidazoline hydrochloride and 48.4 g of 2,3-dimethylaniline are refluxed for 5 hours in 65 ml of absolute ethanol. After cooling, the crystallised substance is collected by suction and recrystallised from water, affording 36 g (77% yield) of the final product with a melting point of 242° C.

Workup

  1. temperatureAfter cooling
  2. customthe crystallised substance is collected by suction
  3. customrecrystallised from water

Sources & evidence

ORD record
ord-e06acf45d0b04201b442b52954b92b8f
Source dataset
uspto-grants-1981_03
Patent number
US04254133

Linked notes

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