1-Phenethylamine → 2-(4-alpha-Methylbenzylaminopropoxyphenyl)-8-methylimidazo[1,2-a]pyridine

HRID 1268690Notes

Reaction equation

HRID 1268690 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:14]3[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]3[CH:21]=2)=[CH:8][CH:7]=1.[CH3:22][CH:23]([NH2:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.C(NCCCC)CCC>>[CH3:22][CH:23]([NH:30][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:14]3[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]3[CH:21]=2)=[CH:8][CH:7]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

4

Reactant 3

HCID 74081-PhenethylamineHCID 8148DibutylamineHCID 142014592-(4-Chloropropoxyphenyl)-8-methylimidazo[1,2-a]pyridine

Product 1

HCID 208031682-(4-alpha-Methylbenzylaminopropoxyphenyl)-8-methylimidazo[1,2-a]pyridine

Procedure

This compound was prepared according to the procedure described in Example 1 of U.S. Pat. No. 4,727,145. using 2-(4-chloropropoxyphenyl)-8-methylimidazo[1,2-a]pyridine and alpha-methylbenzylamine instead of 2-(4-chloropropoxyphenyl)-imidazo[1,2-a]pyridine and dibutylamine respectively. Analysis: Calc'd for C25H27N3O 3HCl; C, 6.11; H, 60.8; N, 8.49. Found: C, 6.51; H, 60.43; N, 8.36.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-0f2afecc4543413e8dd5e67db633a122
Source dataset
uspto-grants-2007_04
Patent number
US07199117B2

Reaction notes

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