Dibutylamine → 2-[4-[3-(4-Phenethylpiperazino)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine

HRID 1268692Notes

Reaction equation

Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:14]3[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]3[CH:21]=2)=[CH:8][CH:7]=1.[CH2:22]([N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1)[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.C(NCCCC)CCC>>[CH2:22]([N:30]1[CH2:31][CH2:32][N:33]([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([C:12]3[N:13]=[C:14]4[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]4[CH:21]=3)=[CH:8][CH:7]=2)[CH2:34][CH2:35]1)[CH2:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

Reactant 3

HCID 8148Dibutylamine

HCID 792141-Phenethylpiperazine

HCID 142014592-(4-Chloropropoxyphenyl)-8-methylimidazo[1,2-a]pyridine

Product 1

HCID 220156502-[4-[3-(4-Phenethylpiperazino)propoxy]phenyl]-8-methylimidazo[1,2-a]pyridine

Procedure

This compound was prepared according to the procedure described in Example 1 of U.S. Pat. No. 4,727,145. using 2-(4-chloropropoxyphenyl)-8-methylimidazo[1,2-a]pyridine and N-phenethylpiperazine instead of 2-(4-chloropropoxyphenyl)-imidazo[1,2-a]pyridine and dibutylamine respectively.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-51d43a797ed544399c58ec1e61e67d1e
Source dataset: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07199117B2

Reaction notes

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