4-Chlorophenylboronic acid → 4-Chloro-6-(4-chlorophenyl)-5-methylpyrimidine
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](B(O)O)=[CH:4][CH:3]=1.[Cl:11][C:12]1[C:17]([CH3:18])=[C:16](Cl)[N:15]=[CH:14][N:13]=1.ClC1C(C)=C(C2C=CC(C(F)(F)F)=CC=2)N=CN=1>>[Cl:11][C:12]1[C:17]([CH3:18])=[C:16]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[N:15]=[CH:14][N:13]=1Participants
4
Procedure
Prepared from 4-chlorophenylboronic acid and 4,6-dichloro-5-methylpyrimidine using the procedure described for Intermediate 62.
Sources & evidence
- ORD record
- ord-34e1acba25df482aaa791880e67fd1e2
- Source dataset
- uspto-grants-2007_04
- Patent number
- US07199239B2
Reaction notes
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