4-Chloro-6-(4-chlorophenyl)-5-methylpyrimidine → Ethyl (4-{[[6-(4-chlorophenyl)-5-methylpyrimidin-4-yl](propyl)amino]methyl}-2-methylphenoxy)acetate
Reaction equation
Cl[C:2]1[C:7]([CH3:8])=[C:6]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH3:16][C:17]1[CH:29]=[C:28]([CH2:30][N:31](C2C(C)=C(C3C=CC(C(F)(F)F)=CC=3)N=CN=2)[CH2:32][CH2:33][CH3:34])[CH:27]=[CH:26][C:18]=1[O:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([C:6]2[N:5]=[CH:4][N:3]=[C:2]([N:31]([CH2:30][C:28]3[CH:27]=[CH:26][C:18]([O:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])=[C:17]([CH3:16])[CH:29]=3)[CH2:32][CH2:33][CH3:34])[C:7]=2[CH3:8])=[CH:10][CH:11]=1Participants
3
Reactant 2
Product 1
Procedure
Using 4-chloro-6-(4-chlorophenyl)-5-methylpyrimidine (167 mg, 0.7 mmol) and the synthetic procedure described for Intermediate 80. Purification by Biotage™ chromatography (Si, 40 g) eluting 9:1 cyclohexane:EtOAc afforded the title compound as a pale yellow oil (116 mg).