4-Chloro-5-methyl-6-(4-methylphenyl)pyrimidine → Ethyl (2-methyl-4-{[[5-methyl-6-(4-methylphenyl)pyrimidin-4-yl](propyl)amino]methyl}phenoxy)acetate
Reaction equation
ClC1C(C)=C(C2C=CC(C)=CC=2)N=CN=1.[CH3:16][C:17]1[CH:29]=[C:28]([CH2:30][N:31]([C:35]2[C:40]([CH3:41])=[C:39]([C:42]3[CH:47]=[CH:46][C:45]([C:48](F)(F)F)=[CH:44][CH:43]=3)[N:38]=[CH:37][N:36]=2)[CH2:32][CH2:33][CH3:34])[CH:27]=[CH:26][C:18]=1[O:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[CH3:16][C:17]1[CH:29]=[C:28]([CH2:30][N:31]([C:35]2[C:40]([CH3:41])=[C:39]([C:42]3[CH:43]=[CH:44][C:45]([CH3:48])=[CH:46][CH:47]=3)[N:38]=[CH:37][N:36]=2)[CH2:32][CH2:33][CH3:34])[CH:27]=[CH:26][C:18]=1[O:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]Participants
3
Reactant 2
Product 1
Procedure
Using 4-chloro-5-methyl-6-(4-methylphenyl)pyrimidine (153 mg, 0.7 mmol) and the synthetic procedure described for Intermediate 80. Purification by Biotage™ chromatography (Si, 40 g) eluting 9:1 cyclohexane:EtOAc afforded the title compound as a pale yellow oil (80 mg).