4-Chloro-6-(4-methoxyphenyl)-5-methylpyrimidine → Ethyl (2-methyl-4-{[{5-methyl-6-[4-(methyloxy)phenyl]pyrimidin-4-yl}(propyl)amino]methyl}phenoxy)acetate
Reaction equation
Cl[C:2]1[C:7]([CH3:8])=[C:6]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH3:17][C:18]1[CH:30]=[C:29]([CH2:31][N:32](C2C(C)=C(C3C=CC(C(F)(F)F)=CC=3)N=CN=2)[CH2:33][CH2:34][CH3:35])[CH:28]=[CH:27][C:19]=1[O:20][CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23]>>[CH3:17][C:18]1[CH:30]=[C:29]([CH2:31][N:32]([C:2]2[C:7]([CH3:8])=[C:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=3)[N:5]=[CH:4][N:3]=2)[CH2:33][CH2:34][CH3:35])[CH:28]=[CH:27][C:19]=1[O:20][CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23]Participants
3
Reactant 2
Product 1
Procedure
Using 4-chloro-6-(4-methoxyphenyl)-5-methylpyrimidine (164 mg, 0.7 mmol) and the synthetic procedure described for Intermediate 80. Purification by Biotage™ chromatography (Si, 40 g) eluting 4:1 cyclohexane:EtOAc afforded the title compound as a pale yellow oil (60 mg).