5-{[4-(tetrahydro-2H-pyran-2-yloxy)cyclohexyl]oxy}-1H-indazole → 5-(Pyrrolidin-3-yloxy)-1H-indazole

HRID 1269810

Reaction equation

HRID 1269810 reaction equation
O1CCCCC1OC1C[CH2:12][CH:11]([O:14][C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[NH:20][N:19]=[CH:18]3)[CH2:10][CH2:9]1.[NH:24]1C2C(=CC(OC3CCC(O)CC3)=CC=2)C=N1>>[NH:24]1[CH2:9][CH2:10][CH:11]([O:14][C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[NH:20][N:19]=[CH:18]3)[CH2:12]1

Participants

3

Reactant 2

HCID 184472075-{[4-(tetrahydro-2H-pyran-2-yloxy)cyclohexyl]oxy}-1H-indazoleHCID 229333694-(1H-indazol-5-yloxy)cyclohexanol

Product 1

HCID 229333985-(Pyrrolidin-3-yloxy)-1H-indazole

Procedure

The following compound of Example 379 was synthesized by carrying out reactions according to the methods described in Example 372, (b) and Example 377 except for using the tert-butyl 4-hydroxyazepane-1-carboxylate obtained in Example 322, (c), as a reagent.

Sources & evidence

ORD record
ord-d951db50d9cf45e898ab537e61d46b0e
Source dataset
uspto-grants-2007_04
Patent number
US07199147B2

Linked notes

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