Sodium Hydroxide → 4-(2-Pyridyl)-4-oxo-2-butenoic acid

HRID 126998Notes

Reaction equation

HRID 126998 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7](=[O:14])[CH:8]=[CH:9][C:10]([O:12]C)=[O:11].[OH-].[Na+]>C(Cl)(Cl)Cl.O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7](=[O:14])[CH:8]=[CH:9][C:10]([OH:12])=[O:11]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 867375424-(2-Pyridyl)-4-oxo-2-butenoic acid, methyl ester

Product 1

HCID 541116954-(2-Pyridyl)-4-oxo-2-butenoic acid

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6212ChloroformSolvent

Procedure

A mixture of 15 g of 4-(2-pyridyl)-4-oxo-2-butenoic acid, methyl ester in chloroform (50 ml) is stirred with 3.14 g of sodium hydroxide in 50 ml of water for 5 hours at room temperature. The aqueous layer is separated, washed with chloroform and acidified with 4.71 g of acetic acid, yielding the title compound.

Workup

  1. customThe aqueous layer is separated
  2. washwashed with chloroform

Sources & evidence

ORD record
ord-aa0ab47e1815402481c8ae032491d1c9
Source dataset
uspto-grants-1981_03
Patent number
US04254267

Reaction notes

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