Propylene Oxide → 1-(2-Benzyl-4-chlorophenoxy)propan-2-ol

HRID 127122

Reaction equation

HRID 127122 reaction equation
[CH2:1]([C:8]1[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=1[OH:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:16]1[O:19][CH:17]1[CH3:18]>[OH-].[Na+]>[CH2:1]([C:8]1[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=1[O:15][CH2:16][CH:17]([OH:19])[CH3:18])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6378Propylene OxideHCID 8425Chlorophene

Product 1

HCID 202860201-(2-Benzyl-4-chlorophenoxy)propan-2-ol

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideCatalyst

Procedure

2-Benzyl-4-chlorophenol (43.7 parts) is propoxylated with propylene oxide (12.6 parts) using sodium hydroxide (0.2 part) as catalyst at 145° C. in a manner similar to that used in Example 10 to give 1-(2-benzyl-4-chlorophenoxy)propan-2-ol (16.3 parts)

Workup

  1. customat 145° C.

Sources & evidence

ORD record
ord-e058165be7c8495780fba51b6de57c84
Source dataset
uspto-grants-1981_03
Patent number
US04255152

Linked notes

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