5-Hydroxynicotinic acid → 5-Hydroxy-nicotinic acid isopropyl ester

HRID 1271649Notes

Reaction equation

HRID 1271649 reaction equation
Cl[C:2]1[CH:10]=CC(C(O)=O)=C[C:3]=1O.[OH:12][C:13]1[CH:14]=[N:15][CH:16]=[C:17]([CH:21]=1)[C:18]([OH:20])=[O:19]>>[CH:2]([O:19][C:18](=[O:20])[C:17]1[CH:21]=[C:13]([OH:12])[CH:14]=[N:15][CH:16]=1)([CH3:10])[CH3:3]

Participants

3

Reactant 2

HCID 340375-Hydroxynicotinic acidHCID 1418724-Chloro-3-hydroxybenzoic acid

Product 1

HCID 639254745-Hydroxy-nicotinic acid isopropyl ester

Procedure

The title compound was synthesized by substituting 4-chloro-3-hydroxybenzoic acid in Example 116A with 5-hydroxy-nicotinic acid. MS (DCI) m/z 182(M+H)+.

Sources & evidence

ORD record
ord-0fc7517a288e49bb935bfc9916758958
Source dataset
uspto-grants-2007_04
Patent number
US07205409B2

Reaction notes

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