5-(4-(3,4-Dimethoxyphenyl)piperidino)-3-(4-methylphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol → 4-(3,4-Dimethoxyphenyl)-1-(3-(4-methylphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperidine
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]2[CH2:16][CH2:15][N:14]([C:17]3[C:18]([CH3:38])=[C:19]([CH3:37])[C:20]4[O:24][C:23]([CH3:26])([CH3:25])[C:22]([C:28]5[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][CH:29]=5)(O)[C:21]=4[C:35]=3[CH3:36])[CH2:13][CH2:12]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]>CCCCCC.CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]2[CH2:12][CH2:13][N:14]([C:17]3[C:18]([CH3:38])=[C:19]([CH3:37])[C:20]4[O:24][C:23]([CH3:26])([CH3:25])[CH:22]([C:28]5[CH:33]=[CH:32][C:31]([CH3:34])=[CH:30][CH:29]=5)[C:21]=4[C:35]=3[CH3:36])[CH2:15][CH2:16]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Using 5-(4-(3,4-dimethoxyphenyl)piperidino)-3-(4-methylphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol obtained in Example 78, the title compound was synthesized in the same manner as in Example 46. Yield 51%. mp. 103–105° C. (hexane-methanol).