Ethanol → Phenylpyruvic acid 3,4-dichlorophenylhydrazone

HRID 127298

Reaction equation

HRID 127298 reaction equation
O.[C:2]1([CH2:8][C:9](=O)[C:10]([O-:12])=[O:11])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Na+].Cl.[Cl:16][C:17]1[CH:18]=[C:19]([NH:24][NH2:25])[CH:20]=[CH:21][C:22]=1[Cl:23].C(O)C>O>[Cl:16][C:17]1[CH:18]=[C:19]([NH:24][N:25]=[C:9]([CH2:8][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:10]([OH:12])=[O:11])[CH:20]=[CH:21][C:22]=1[Cl:23]

Participants

5

Reactant 3

HCID 702EthanolHCID 3084323(3,4-Dichlorophenyl)hydrazine monohydrochlorideHCID 23666336Sodium phenylpyruvate monohydrate

Product 1

HCID 86737587Phenylpyruvic acid 3,4-dichlorophenylhydrazone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Add 21.0 g of sodium β-phenylpyruvate monohydrate and 21.3 g of 3,4-dichlorophenylhydrazine hydrochloride to 300 ml of ethanol and reflux the resulting mixture for 30 minutes. Cool, add water, collect and dry the solid to yield phenylpyruvic acid 3,4-dichlorophenylhydrazone, m.p. 166°-167°.

Workup

  1. temperaturereflux the resulting mixture for 30 minutes
  2. temperatureCool
  3. customcollect
  4. customdry the solid

Sources & evidence

ORD record
ord-100280779c1043beb3ff7c579af99199
Source dataset
uspto-grants-1981_03
Patent number
US04255442

Linked notes

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