Hydrochloric Acid → 2-Benzofuryl (2,3-dichloro-4-methoxy-phenyl) ketone

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Reaction Steps

14 g (0.1 mole) of aluminium chloride are introduced little by little in a solution of 16 g (0.09 mole) of 2,3-dichloro-anisol and 16 g (0.09 mole) of 2-benzofurancarboxylic acid chloride in 200 ml of methylene chloride the mixture is taken up to reflux for 4 hours, then poured on crushed ice (300 g) and concentrated hydrochloric acid (10 ml); the precipitate is filtered off, washed with an aqueous solution of sodium hydroxide (10 N), then with water and dried. 22 g of 2-benzofuryl (2,3-dichloro-4-methoxy-phenyl) ketone are obtained. Melting point 148° C. after crystallization from ethylacetate.

Provenance & Evidence