Thiourea → HCID 21699321, compound
Reaction equation
[NH2:1][C:2]([NH2:4])=[S:3].[Cl:5][C:6]1[C:7](=[O:15])[NH:8][C:9](=[O:14])[NH:10][C:11]=1[CH2:12]Cl>C(O)C>[ClH:5].[Cl:5][C:6]1[C:7](=[O:15])[NH:8][C:9](=[O:14])[NH:10][C:11]=1[CH2:12][S:3][C:2](=[NH:4])[NH2:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 140 mg of thiourea in ethanol (3 ml), 300 mg of 5-chloro-6-chloromethyluracil were added, followed by heating for 6 hours under reflux. After the reaction mixture was allowed to cool down, a crystallized matter was collected by filtration, whereby 337 mg of the title compound were obtained (yield: 81%).
Workup
- temperatureby heating for 6 hours
- temperatureunder reflux
- temperatureto cool down
- filtrationa crystallized matter was collected by filtration
Sources & evidence
- ORD record
- ord-e1e4c92caa184635aa17c934869cef21
- Source dataset
- uspto-grants-2000_12
- Patent number
- US06159969
Reaction notes
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